Devil's Claw
Last updated: November 20, 2020

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After a certain age, many of us start experiencing joint pain. We can feel discomfort in our lower back, knees, and hips as a result of physical activity or simply as a consequence of the passage of time. But does that mean you have to accept living with this discomfort day after day?

The devil’s claw or Harpagophytum is a plant with known analgesic properties. Despite being a traditional remedy, medical agencies around the world have recognized its potential to relieve minor joint pains. If you want to learn more about the benefits of this natural remedy, keep reading our guide!

Key Facts

  • The devil’s claw is an African plant with analgesic, antioxidant, and anti-inflammatory properties.
  • Various studies carried out throughout the globe have demonstrated that it could contribute to alleviating certain articular and digestive discomforts.
  • You should consider various factors before purchasing devil’s claw supplements. These include dietary restrictions you may have, the part of the plant used in the product, and its harpagoside concentration, among others.

Our Selection: The Best Devil’s Claw Supplements on the Canadian Market

The analgesic effect of products containing devil’s claw can vary greatly, each formulation offering very different results. To help you make the right decision, we have selected some of the most popular supplements currently available on the Canadian market:

Best Devil’s Claw Tablet Supplement

This products dry extract is a standardized form of devil’s claw root containing harpagoside, which is proven to contribute to the herb’s clinical efficacy and pharmacological actions. Improvements in joint mobility and functionality occur as a result of reduced pain and inflammation when using this devil’s claw extract. Symptoms of inflammation, pain, swelling, redness, stiffness, reduced mobility and strain can be reduced and improved using devil’s claw.

Pascoe Agil is traditionally used to help treat inflammation of the joints. It is made with naturally sourced medicinal ingredients and contains 240mg of devil’s claw (Harpagophytum procumbens) dry extract per tablet. Use Pascoe Agil tablets to help relieve painful joints, inhibit inflammation in joints and improve the mobility of joints.

Best Devil’s Claw Ointment

With devil’s claw root extract lyophilized titrated harpagoside 2%. Ointment Claw is an innovative product characterized by the presence of the extract lyophilized devil’s claw root. This product ensures a high concentration of active ingredients. Together with the essential oil of cajeput, it is useful to give elasticity to the skin areas and wellness concerned.

This ointment is particularly effective if applied with a prolonged massage. More so, this product is made according to the standard production, “Standard for the obtaining of organic cosmetics”, which involves the use of raw materials from organic agriculture.

Best Devil’s Claw Capsules for Vegetarian Diets

Devil’s claw is abundant in naturally occurring bioactive compounds including harpagoside, phytosterols, phenolic acids and flavonoids. Some studies suggest that these compounds may help to support joint comfort through their ability to promote a healthy response to typical everyday joint stress. This well known brand delivers 100 veggie capsules per bottle.

Each one of Now Food`s capsules contains 166mg of devil’s claw extract. Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Please note that this supplement is not recommended for minors.

Best Devil’s Claw Supplement Overall

This is an Amazon’s Choice overall devil’s claw supplement. It contains anti-inflammatory components to help relieve joint pain. It has been formulated to help with back pain and osteoarthritis. It is also said to support a quick and efficient reduction of pain. This extra strong formula comes in a 130 count bottle, and each capsule contains 275mg of devil’s claw extract.

This manufacturer is a proud Canadian company, providing consumers with the highest-quality natural products, vitamins and supplements. Their customers are their most cherished asset, to whom they offer a promise of quality, satisfaction and health improvement.

Best Devil’s Claw Liquid Supplement

We know that liquid supplements are a favorite among people who have trouble swallowing softgels and tablets. Nature’s Answer brings you this alcohol-free devil’s claw root liquid extract, with a whopping 1,000 mg of Harpagophytum per serving.

The recommended dose is 28 drops in water, three times a day. Available in a 1-fluid ounce bottle. Additionally, each serving of this extract contains 350mg of devil’s claw. The suggested use is to take 28 drops three times a day in a small amount of water.

Shopping Guide: Everything You Should Know About Devil’s Claw

The devil’s claw is an African plant with medicinal properties recognized for treating joint and digestive discomforts. However, the effectiveness of supplements containing this ingredient may vary depending on the concentration of therapeutic active components.

The devil’s claw is known for its anti-inflammatory and analgesic properties.
(Source: Ragiboglu: 88262051/ 123rf.com)

What is the devil’s claw exactly?

Harpagophytum procumbens, also known as devil’s claw or grapple plant, is a plant native to southern Africa. Since time immemorial, it has been considered a traditional medicinal remedy used for a variety of conditions, ranging from fever to diabetes or blood diseases (1).

Its medicinal properties reside in its roots, and more specifically in the secondary tuberous roots. Once this part of the plant is dried, the powder obtained can be added to decoctions, infusions, or poultices. Nowadays, you can also find liquid and dry extracts from the root of the devil’s claw (2).

What are the properties of this plant?

When we examine the root of the devil’s claw, we notice that it contains a large number of different compounds. These substances include amino acids, carbohydrates, flavonoids, and phytosterols. However, its active principle is the harpagoside, a molecule that seems to be responsible for most of the plant’s effects on the organism.

Unfortunately, scientists are yet to fully understand its mechanism of action. Despite this great mystery, devil’s claw extract has been shown to exert anti-inflammatory, analgesic, and antioxidant effects, among others. You can find out more about these properties in the table below (1):

Activity Description
Antinflammatory In animals, it reduces joint inflammation.

In vitro (on isolated cells), it inhibits the secretion of inflammatory molecules.

Analgesic In animals, it reduces sensitivity to painful stimuli.
Antioxidant In vitro and in animals, the devil’s claw extract proves to be able to capture and neutralize free radicals.
Antimicrobial In vitro, the harpagoside molecule prevents the reproduction of the human herpesvirus 1 (HSV-1).

In vitro, the extract prevents the growth of the Candida krusei fungus.

Antidiabetic In animals, it reduces the concentration of blood sugar.
Antimalarial In vitro, it shows activity against the parasite responsible for malaria (Plasmodium falciparum). 

In addition, the devil’s claw may have effects on the nervous system by helping to reduce seizures, the cardiac system by relaxing the myocardium, and at the gynecological level by increasing uterine contractions. Researchers have also explored a potential link between this plant and an anti-tumor effect, due to its anti-inflammatory and antioxidative properties (1).

There is no doubt that these findings are very promising. The real question is, can these effects influence the human body? The previous data, obtained from animal models (laboratory rats) or from cells in controlled environments (in vitro), isn’t enough to confirm the validity or safety of devil’s claw products in humans.

Is devil’s claw really effective?

The alleged healing properties of this plant have attracted the attention of experts in Western medicine. Several studies have been conducted on human volunteers and have produced exciting results. In that regard, the European Medicines Agency (EMA) – the equivalent of the FDA – has reached several conclusions about the effectiveness of the devil’s claw (2):

  • Useful for relieving joint pain: According to the EMA, these supplements can be used to soothe joint discomfort, as long as its intensity is mild.
  • Potential improvement of digestive discomfort: Devil’s claw can also be used to relieve gastrointestinal symptoms such as bloating or flatulence.
  • Possible treatment for poor appetite: According to European experts, the extract could help improve lack of appetite.

Note that these treatments are suitable for healthy adults. In any case, you should consult a doctor if joint discomfort persists after four weeks of treatment. For digestive pathologies, you must seek specialized help if you see no improvement in your condition after two weeks of supplementation with devil’s claw (2).

Keep in mind that the Committee on Herbal Medicinal Products (HMPC) has warned of the little information available on this plant. While it has been safely used in traditional medicine for over 30 years, its mechanism of action remains a mystery (2, 3).

Pros Cons
Remedy used safely for over 30 years Little information regarding its mechanism of action
Relief of joint pain and joint inflammation from arthritis Small, inconsistently designed clinical trials with no placebo controls
Relief of digestive discomfort and lack of appetite Presence of side effects and hypersensitivity
According to some studies, it may reduce the consumption of drugs such as ibuprofen. The effects can change depending on the formulation (harpagoside concentration) of each product.

How should I use devil’s claw products?

There are dozens of different ways to use it as a traditional remedy. Whether in decoctions, tinctures, or poultice, this plant is very versatile. Its effectiveness, therefore, will vary depending on the dosage and the harpagoside concentration in the preparation.

However, Western medicine has tried to standardize the use of these supplements as much as possible. Thus, the Cochrane organization (4) states that Harpagophytum-based formulations that have proven to be useful in relieving joint pain contain between 50-100 milligrams of harpagoside.

When buying a supplement with devil’s claw, you should look at the amount of the plant’s extract and the harpagoside concentration inside.

Natural remedy experts generally use a daily dose of harpagoside ranging from 1 to 3 grams for joint pain. You can also drink infusions for gastric discomfort (5). Find out more about these recommendations in the following table (4, 5, 6):

Description
Daily dose of devil’s claw 1-3 grams of dry extract (joint pain)

1.5 gram in decoction (gastric discomfort)

Harpagoside concentration (Cochrane) 50-100 milligrams
Traditional posology for infusions (EMA) 4.5 g of powder in 500 milliliters of boiling water. Divide it into three doses to be taken every eight hours.
Traditional posology for dry extract (EMA) 100-1,200 mg, two to three times a day.

(Maximum daily dose: 2.4 g)

Traditional liquid posology (EMA) 0.5-1 ml, three times a day.

(Maximum daily dose: 3 ml)

How can I choose a suitable devil’s claw product?

A lot of supplements available on the Canadian market won’t necessarily follow the recommendations listed above. Don’t worry; many manufacturers use their own studies to create their formulas. In that case, you may be asking yourself how you can get the most out of these products.

  • Search for a reliable manufacturer: Stick to recognized and experienced nutrition brands. If you can, look for information regarding the laboratory and the origin of the raw material.
  • Opt for a formula as close as possible to the official indications: Many devil’s claw products provide a lower amount of harpagoside than the Cochrane organization recommends. However, you can find supplements that contain enough root, both in liquid and solid form.
  • Follow the manufacturer’s instructions: You should never improvise while using dietary supplements, even to try and match the quantities recommended by the most prestigious studies. Following the brand’s guidelines is the best way to minimize the likelihood of side effects.

So, are all preparations equally effective? According to experts, we find wide variations between the harpagoside concentration of different supplements, which influences their effectiveness (7, 8). This means that the results may be better with one manufacturer than another.

We should also mention the creams and gels based on devil’s claw.

These products may contain different concentrations of this plant and often contain a multitude of other ingredients. Once again, we encourage you to choose a safe brand that offers a formula that is as pure as possible. If you’re not happy with the results, don’t hesitate to change supplements!

Check in with your physician if your pain doesn’t improve after four weeks of treatment (two weeks for digestive conditions). In any case, these products cannot replace professional care. Any new discomfort (joint or digestive) requires medical attention to rule out any potentially dangerous problems.

The medicinal substances of the devil’s claw are found in its tuberous roots.
(Source: Lotus Salvinia.de: 16322672377/ Flickr.com)

Are there side effects or contraindications?

This plant is considered safe for healthy adults as long as they follow the manufacturer’s instructions. The devil’s claw could cause the side effects listed below if misused or by population groups that are particularly sensitive to the extract (9, 10):

  • Digestive symptoms: Paradoxically, the devil’s claw may worsen digestive conditions in specific individuals, causing nausea, vomiting, diarrhea, or abdominal pain.
  • Hypersensitivity reactions: It could produce allergic reactions that generally affect the skin, causing a rash that may result in itching. Swelling of the face is a particularly severe symptom that requires immediate medical assistance.
  • Aggravations of gastric ulcers: The devil’s claw can stimulate gastric secretion, causing ulcers in predisposed people or aggravating preexisting lesions.
  • Hypertension: There have been reports of cases of hypertension as a consequence of the consumption of devil’s claw. This is why you should be particularly cautious with these supplements if you suffer from hypertension or prehypertension.
  • Effects on pregnancy: Experts strongly advise against the use of this plant during pregnancy. In animal experiments, it is capable of stimulating the development of uterine contractions, even bringing forward the birth and endangering the life of the fetus.
  • Blood clotting disorders: The devil’s claw can cause alterations in hemostasis (the mechanisms that stop and control bleeding). Individuals with hemorrhages or coagulation problems should refrain from using it.
  • Other symptoms: This plant can also cause dizziness, headache, and loss of appetite in the most sensitive people. People weakened by kidney, heart, liver, or lung failure should stay away from these supplements, as they could aggravate those conditions.

In addition, this herbal remedy can affect the function of a large number of drugs. If you are currently following a pharmacological treatment, you are advised to consult with a physician regarding the potential interactions between the devil’s claw and your medication. Here is a list of the most common ones (10):

Drug group Examples
Antiarrhythmics and cardiac function regulators Digoxin, bisoprolol, and atropine
Antidiabetics Insulin and biguanides (metformin)
Blood-thinning and antiplatelet medication Warfarin, aspirin, acenocoumarol (sintrom), and heparin
Hepatic metabolism drugs (cytochromes P450) Antibiotics, antifungals, antidepressants, antihypertensives, and analgesics
Antacids Omeprazole and ranitidine

In addition, you must keep in mind that the devil’s claw may be harmful to children and should, therefore, not be given to minors. Its use is also prohibited during pregnancy and breastfeeding. Always consult your physician if you plan on using these supplements for over four months in a row, as the safety of the long-term treatment is still unknown (10).

Buyer’s Guide

There is a wide variety of Harpagophytum-based supplements on the market, and the differences in their formulas make it challenging to find an appropriate product. To help you make the right purchase, you should keep the following criteria in mind:

Dietary Restrictions

The laboratories that produce devil’s claw supplements often handle products with gluten, soy, and lactose, among other allergens. Besides, the capsules may contain gelatin of animal origin. If you are prone to allergies or vegan, don’t forget to check the product before purchasing it.

The label of every nutritional supplement should include detailed information regarding its ingredients and traces of allergens. If you opt for liquid products, you may want to make sure they don’t contain ethanol; this is not suitable for individuals with alcohol dependency.

The devil’s claw is particularly well-liked by phytotherapists.
(Source: Avogel Schweiz: 5599670961/ Flickr.com)

Type of Extract

Remember that the harpagosides responsible for the analgesic effect are concentrated in the secondary root of the plant (1). High-quality products should specify that it contains Harpagophytum root or root extract. Products containing leaves, flowers, or the generic grapple plant are likely to be much less effective.

Harpagoside Content

The unique molecule of the devil’s claw can be found in varying concentrations depending on the supplement. You are advised to purchase a product with 50 to 100 milligrams of harpagoside. You should find the concentration of this molecule (in grams or as a percentage) on the label.

Summary

Devil’s claw root extract is a product that fascinates phytotherapy experts. It may relieve the discomfort caused by joint wear and even help control the inflammation of arthritis. In addition, this plant may also treat stomach pain and lack of appetite.

Scientists are starting to recognize the effectiveness of the devil’s claw based on the good results of medicinal therapies. However, it is essential that you take a quality supplement with a sufficient concentration to make the most of this plant. Are you ready to give this natural remedy a go?

We hope that you found our guide helpful and informative. Feel free to give us your opinion below, and don’t forget to share this article with your friends and family!

(Featured Image Source: Rau: 12203525/ 123rf.com)

References (10)

1. Mncwangi N, Chen W, Vermaak I, Viljoen AM, Gericke N. Devil’s Claw – A review of the ethnobotany, phytochemistry and biological activity of Harpagophytum procumbens. J Ethnopharmacol [Internet]. 2012;143(3):755–71.
Source

2. Harpagophyti radix | European Medicines Agency [Internet]. [cited 2020 Apr 1].
Source

3. Gagnier JJ, Chrubasik S, Manheimer E. Harpgophytum procumbens for osteoarthritis and low back pain: A systematic review. BMC Complement Altern Med [Internet]. 2004 Dec 15 [cited 2020 Apr 3];4(1):13.
Source

4. ltean H, Robbins C, van Tulder MW, Berman BM, Bombardier C, Gagnier JJ. Herbal medicine for low-back pain. Vol. 2014, Cochrane Database of Systematic Reviews. John Wiley and Sons Ltd; 2014.
Source

5. Carretero Accame ME, Ortega Hernández-Agero T, Villar del Fresno ÁM. Harpagofito [Internet]. Farmacia Profesional. 2003 [cited 2020 Apr 3]. p. 3.
Source

6. Committee on Herbal Medicinal Products (HMPC). Community Herbal Monograph on Harpagophytum Procumbens Dc. and/or Harpagophytum Zeyheri Decne, Radix. Eur Med Agency [Internet]. 2008;44(November):1–7.
Source

7. Ouitas NA, Heard C. Estimation of the relative antiinflammatory efficacies of six commercial preparations of Harpagophytum procumbens (Devil’s Claw). Phyther Res [Internet]. 2010 Mar [cited 2020 Apr 1];24(3):333–8.
Source

8. Vlachojannis J, Roufogalis BD, Chrubasik S, Chrubasik J. Systematic review on the safety of Harpagophytum preparations for osteoarthritic and low back pain. Vol. 22, Phytotherapy Research. 2008. p. 149–52.
Source

9. Devil’s Claw: Uses, Side Effects, Interactions, Dosage, and Warning [Internet]. [cited 2020 Mar 31].
Source

10. Devil’s Claw Uses, Benefits & Dosage – Drugs.com Herbal Database [Internet]. [cited 2020 Apr 3].
Source

Why you can trust me?

Review article
Mncwangi N, Chen W, Vermaak I, Viljoen AM, Gericke N. Devil’s Claw – A review of the ethnobotany, phytochemistry and biological activity of Harpagophytum procumbens. J Ethnopharmacol [Internet]. 2012;143(3):755–71.
Go to source
Official EMA Report
Harpagophyti radix | European Medicines Agency [Internet]. [cited 2020 Apr 1].
Go to source
Systematic review
Gagnier JJ, Chrubasik S, Manheimer E. Harpgophytum procumbens for osteoarthritis and low back pain: A systematic review. BMC Complement Altern Med [Internet]. 2004 Dec 15 [cited 2020 Apr 3];4(1):13.
Go to source
Cochrane Library
ltean H, Robbins C, van Tulder MW, Berman BM, Bombardier C, Gagnier JJ. Herbal medicine for low-back pain. Vol. 2014, Cochrane Database of Systematic Reviews. John Wiley and Sons Ltd; 2014.
Go to source
Review article
Carretero Accame ME, Ortega Hernández-Agero T, Villar del Fresno ÁM. Harpagofito [Internet]. Farmacia Profesional. 2003 [cited 2020 Apr 3]. p. 3.
Go to source
Official EMA Report
Committee on Herbal Medicinal Products (HMPC). Community Herbal Monograph on Harpagophytum Procumbens Dc. and/or Harpagophytum Zeyheri Decne, Radix. Eur Med Agency [Internet]. 2008;44(November):1–7.
Go to source
Scientific study
Ouitas NA, Heard C. Estimation of the relative antiinflammatory efficacies of six commercial preparations of Harpagophytum procumbens (Devil’s Claw). Phyther Res [Internet]. 2010 Mar [cited 2020 Apr 1];24(3):333–8.
Go to source
Review article
Vlachojannis J, Roufogalis BD, Chrubasik S, Chrubasik J. Systematic review on the safety of Harpagophytum preparations for osteoarthritic and low back pain. Vol. 22, Phytotherapy Research. 2008. p. 149–52.
Go to source
Official website
Devil’s Claw: Uses, Side Effects, Interactions, Dosage, and Warning [Internet]. [cited 2020 Mar 31].
Go to source
Official website
Devil’s Claw Uses, Benefits & Dosage – Drugs.com Herbal Database [Internet]. [cited 2020 Apr 3].
Go to source